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HPV infection pathways

HPV is primarily transmitted through skin-to-skin or skin-to-mucosal contact. Viral particles can penetrate the skin and mucosal surfaces through tiny injuries and infect basal epithelial cells. The following are the routes of HPV transmission:

Gentle-to-genital contact: This includes vulva, vagina, anus, and penis contact.

Oral-to-genital contact: Transmission can occur through mouth-to-vulva, mouth-to-penis, and mouth-to-anus contact.

Hand-to-genital contact: HPV can also be transmitted by touching the genitals with hands that have touched an infected area.

Vertical transmission: HPV can be transmitted from mother to baby during childbirth, although this is less common.
Contact with surfaces or objects: Although less common, the virus can also be spread by touching a surface or object that has the virus on it.
Autoinfection: The virus can spread from one area of the body to another by touching a wart or infected area and then touching another area of the body.

McMurray, H. R., Nguyen, D., Westbrook, T. F., & McAnce, D. J. (2001). Biology of human papillomaviruses. International journal of experimental pathology, 82(1), 15-33.
Petca, A., Borislavschi, A., Zvanca, M. E., Petca, R. C., Sandru, F., & Dumitrascu, M. C. (2020). Non-sexual HPV transmission and role of vaccination for a better future. Experimental and therapeutic medicine, 20(6), 1-1.

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